NY's easy. I've driven through Manhattan several times, no sweat. It's pretty much a grid of alternating one-ways, and there are no real rules. I can deal with that.
Places like DC, Boston, Atlanta, etc., it's all curves and spirals, some one-ways some both ways, some rules are always followed, some part of the time, some never. That's the kind of shit that'll get an out-of-towner killed.
In ATL, the streets were all built to follow the railroad tracks, which were in turn built to avoid hills and streams - or the roads were built to get to and from the mills on those streams. Nothing is even remotely close to square. The city map looks like a bowl of fucking spaghetti.